Cancer's Sneaky Strategy: How It Rewrites Your Liver's Rulebook

Cancer releases molecules that modify the liver, causing inflammation, fat accumulation, and disruption of detoxification processes.

[{"selector":"#anim-015492b5-4c56-4a76-aee8-2c5028a8212a","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-8921ea33-7a4c-4fae-9ad0-a6339dad3768","keyframes":{"transform":["translate3d(-100%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-61ad8e53-571c-415c-b0cd-299e65c3ef23","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-02748579-7bfd-4d23-94f7-6ca08ba6492d","keyframes":{"transform":["translate3d(-110.9756%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] The findings offer insight into cancer's survival strategies and potential for new diagnostics and therapeutics.

[{"selector":"#anim-d65f89c7-55d5-4a68-902c-adfe781be872","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d9edecfa-a165-4db1-b901-70eecb1e42d1","keyframes":{"transform":["translate3d(-100%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-03817920-6e1a-4ca8-9833-48e5a63f43be","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-7868768d-3f71-4ee7-8213-94d08added0e","keyframes":{"transform":["translate3d(-110.9756%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Tumors can lead to systemic complications, including liver disease, but future treatments may address these complications.

[{"selector":"#anim-1b687ccf-0856-4007-8dba-3f74dfd2f557","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-2a45785b-b4b9-4ffd-ab89-5a98c2f1c9dd","keyframes":{"transform":["translate3d(-100%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-2697f3d7-13b6-4808-bae5-540482b7031c","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-16b0ade6-e25e-4c3c-96b9-1f3bfe2e0969","keyframes":{"transform":["translate3d(-110.9756%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Previous research revealed that pancreatic cancers prepare the liver to support the growth of metastatic tumors.

[{"selector":"#anim-5c0a4494-5fd9-43ba-974b-fa92fdc39dfa","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-36a300d3-50ef-4eb4-a952-71fd2d49ffe2","keyframes":{"transform":["translate3d(-100%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-f610cca9-1d53-44a2-910b-c52654cb7f57","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-fd152d89-5187-4548-be79-a1f218005861","keyframes":{"transform":["translate3d(-110.9756%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Distant cancer cells induce fat accumulation in liver cells, reprogramming the liver similar to fatty liver disease.

[{"selector":"#anim-8aaa1aab-6986-4bcc-b577-e988821d046b","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-cebfc0aa-6c91-4bfa-98a3-143abb495bcc","keyframes":{"transform":["translate3d(-100%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-1c0f142c-7fe4-4522-8cd0-8a8d0a99c9cc","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-01038e16-63a1-4f6e-9f24-4c8b4f61221f","keyframes":{"transform":["translate3d(-110.9756%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Reprogrammed livers exhibit high inflammation levels and reduced drug-metabolizing enzymes, impacting chemotherapy tolerance.

[{"selector":"#anim-b0521990-eab2-436f-8b94-f36c5d135104","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-cdb6c623-319f-4c30-8ba2-97fa606e8801","keyframes":{"transform":["translate3d(-100%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-dde3f747-ca17-4496-ae17-322b4b66f8d6","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-38f166c1-3e7a-466d-b0c2-e5a5174a773b","keyframes":{"transform":["translate3d(-110.9756%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] The liver reprogramming is caused by extracellular vesicles (EVPs) released by distant tumors carrying fatty acids.

[{"selector":"#anim-509e75cf-e2b9-4a2c-9a07-607e2f9273c6","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-68c3e2ec-788c-4cc9-83f5-6c153d868213","keyframes":{"transform":["translate3d(-100%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-54294f09-6d33-4294-b9dd-bef3140fffdf","keyframes":{"opacity":[0,1]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-87129c36-e479-46af-8e79-7681ab505fe5","keyframes":{"transform":["translate3d(-110.9756%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":600,"duration":1800,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] The fatty liver condition may benefit cancers by providing a lipid-based energy source and potentially weakening anti-tumor immunity.