Cancer releases molecules that modify the liver, causing inflammation, fat accumulation, and disruption of detoxification processes.

The findings offer insight into cancer's survival strategies and potential for new diagnostics and therapeutics.

Tumors can lead to systemic complications, including liver disease, but future treatments may address these complications.

Previous research revealed that pancreatic cancers prepare the liver to support the growth of metastatic tumors.

Distant cancer cells induce fat accumulation in liver cells, reprogramming the liver similar to fatty liver disease.

Reprogrammed livers exhibit high inflammation levels and reduced drug-metabolizing enzymes, impacting chemotherapy tolerance.

The liver reprogramming is caused by extracellular vesicles (EVPs) released by distant tumors carrying fatty acids.

The fatty liver condition may benefit cancers by providing a lipid-based energy source and potentially weakening anti-tumor immunity.